Abstract | BACKGROUND: METHODS: We have studied 60 female patients undergoing minor elective surgery, in a prospective double blinded method. Three groups of 20 patients each was pretreated with either saline (control group), rocuronium 0.05 mg/kg ( rocuronium group) or vecuronium 0.007 mg/kg ( vecuronium group). Three min after the pretreatment, 1.5 mg/kg succinylcholine was injected. Single twitch responses to electrical stimulation were measured. Serum potassium and creatine kinase were respectively measured 5 min after succinylcholine and 24 h after operation. Fasciculations and myalgia on postoperative day 1 and day 2 were evaluated. RESULTS: The incidence of fasciculations was lowest in the rocuronium group, followed by the vecuronium group, and was highest in the control group. The incidence of myalgia on postoperative day 1 was lower in the rocuronium and vecuronium groups than the control group. The increase of serum creatine kinase was similar among the three groups, but there was no increase in serum potassium concentration in any group. No differences of the single twitch responses to electrical stimulation were found between the rocuronium and vecuronium groups. CONCLUSIONS:
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Authors | J H Kim, H Cho, H W Lee, H J Lim, S H Chang, S M Yoon |
Journal | Acta anaesthesiologica Sinica
(Acta Anaesthesiol Sin)
Vol. 37
Issue 4
Pg. 173-8
(Dec 1999)
ISSN: 0254-1319 [Print] China (Republic : 1949- ) |
PMID | 10670114
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Androstanols
- Neuromuscular Depolarizing Agents
- Neuromuscular Nondepolarizing Agents
- Vecuronium Bromide
- Creatine Kinase
- Succinylcholine
- Potassium
- Rocuronium
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Topics |
- Adult
- Androstanols
(therapeutic use)
- Creatine Kinase
(blood)
- Double-Blind Method
- Fasciculation
(prevention & control)
- Female
- Humans
- Middle Aged
- Muscular Diseases
(prevention & control)
- Neuromuscular Depolarizing Agents
(adverse effects)
- Neuromuscular Nondepolarizing Agents
(therapeutic use)
- Potassium
(blood)
- Prospective Studies
- Rocuronium
- Succinylcholine
(adverse effects)
- Vecuronium Bromide
(therapeutic use)
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