HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Bleeding from the small intestine caused by aplysiatoxin, the causative agent of the red alga Gracilaria coronopifolia poisoning.

Abstract
The cause of death by aplysiatoxin poisoning was bleeding from the small intestine in mice. The pathological changes related to the cause and progression of bleeding were studied morphologically. Bleeding from the capillaries was observed 60 min after i.p. treatment at 250 microg/kg, and this was preceded by dilatation of the lymphatic vessel and congestion of capillaries in the lamina propria from 10 min after the injection. At 100 microg/kg i.v., the target vessels were in the lung, where fibrin deposition was observed in the dilated pulmonary artery, and blood flowed out through a gap in the artery. Then, in the small intestine, similar changes appeared to have occurred, and bleeding was induced in two characteristic ways, one through deposition of fibrin in the lumen and the other via distension of the capillary wall.
AuthorsE Ito, H Nagai
JournalToxicon : official journal of the International Society on Toxinology (Toxicon) Vol. 38 Issue 1 Pg. 123-32 (Jan 2000) ISSN: 0041-0101 [Print] ENGLAND
PMID10669017 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Carcinogens
  • Lyngbya Toxins
  • aplysiatoxin
  • Protein Kinase C
  • Tetradecanoylphorbol Acetate
Topics
  • Animals
  • Carcinogens (toxicity)
  • Gastrointestinal Hemorrhage (chemically induced, pathology)
  • Intestinal Mucosa (pathology)
  • Intestine, Small (pathology)
  • Lung (pathology)
  • Lyngbya Toxins (toxicity)
  • Male
  • Mice
  • Mice, Inbred ICR
  • Microscopy, Electron, Scanning
  • Protein Kinase C (metabolism)
  • Pulmonary Artery (pathology)
  • Rhodophyta (chemistry)
  • Tetradecanoylphorbol Acetate (toxicity)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: