Abstract |
High dosage buprenorphine is actually the principal treatment for substitution medication in France. Clinical trials have demonstrated the clinical efficacy of HD buprenorphine for narcotic addiction, but few data are published concerning the prognostic factors of treatment response in daily practice. A naturalistic study was performed in 1998. 200 generalist practitioners were recruited and 956 patients were included. Sociodemographic, medical and addiction history were collected. A quantitative socio-comportemental and medical indicator (SCMI) was performed. The psychometric properties of the SCMI were analyzed. Simple and multivariate analysis was performed. Patients with good social adjustment and past withdrawal are good responders to HD buprenorphine. Not treated psychiatric pathology was a prognostic factor associated with a relatively poor response to HD buprenorphine. A long duration of treatment (one year) and a clear therapeutic program were associated with good response.
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Authors | I Gasquet, C Lançon, P Parquet |
Journal | L'Encephale
(Encephale)
1999 Nov-Dec
Vol. 25
Issue 6
Pg. 645-51
ISSN: 0013-7006 [Print] France |
Vernacular Title | Facteurs prédictifs de réponse au traitement substitutif par buprénorphine haut dosage. Etude naturaliste en médecine générale. |
PMID | 10668610
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Drugs, Generic
- Narcotic Antagonists
- Buprenorphine
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Topics |
- Adolescent
- Adult
- Buprenorphine
(therapeutic use)
- Cross-Sectional Studies
- Dose-Response Relationship, Drug
- Drugs, Generic
- Female
- Humans
- Male
- Narcotic Antagonists
(therapeutic use)
- Primary Health Care
- Prospective Studies
- Substance-Related Disorders
(drug therapy)
- Surveys and Questionnaires
- Treatment Outcome
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