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The farnesyltransferase inhibitor L-744,832 inhibits the growth of astrocytomas through a combination of antiproliferative, antiangiogenic, and proapoptotic activities.

AuthorsM M Feldkamp, N Lau, A Guha
JournalAnnals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 886 Pg. 257-60 ( 1999) ISSN: 0077-8923 [Print] United States
PMID10667233 (Publication Type: Journal Article)
Chemical References
  • Angiogenesis Inhibitors
  • Antineoplastic Agents
  • Enzyme Inhibitors
  • L 744832
  • Methionine
  • Alkyl and Aryl Transferases
  • Farnesyltranstransferase
Topics
  • Alkyl and Aryl Transferases (antagonists & inhibitors)
  • Angiogenesis Inhibitors (pharmacology)
  • Antineoplastic Agents (pharmacology)
  • Apoptosis (drug effects)
  • Astrocytoma (pathology)
  • Brain Neoplasms (pathology)
  • Cell Division (drug effects)
  • Enzyme Inhibitors (pharmacology)
  • Farnesyltranstransferase
  • Humans
  • Methionine (analogs & derivatives, pharmacology)

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