Abstract | OBJECTIVE: The objective of this study was to investigate the nasal toxicity of a mucoadhesive Carbopol 971P formulation of apomorphine. MATERIALS AND METHODS: RESULTS: CONCLUSIONS:
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Authors | M I Ugwoke, R U Agu, M Jorissen, P Augustijns, R Sciot, N Verbeke, R Kinget |
Journal | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
(Eur J Pharm Sci)
Vol. 9
Issue 4
Pg. 387-96
(Feb 2000)
ISSN: 0928-0987 [Print] Netherlands |
PMID | 10664479
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acrylates
- Adhesives
- Dopamine Agonists
- Drug Carriers
- carbopol 974P NF
- Glucose
- Apomorphine
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Topics |
- Acrylates
(administration & dosage, toxicity)
- Adhesives
(administration & dosage, toxicity)
- Administration, Intranasal
- Animals
- Apomorphine
(administration & dosage, toxicity)
- Cells, Cultured
- Cilia
(drug effects, physiology)
- Dopamine Agonists
(administration & dosage, toxicity)
- Dose-Response Relationship, Drug
- Drug Carriers
- Epithelial Cells
(drug effects, physiology)
- Freeze Drying
- Glucose
(administration & dosage)
- Humans
- Male
- Nasal Mucosa
(cytology, drug effects, physiology)
- Rabbits
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