Conjunctival edema and alopecia of the external third of the eyebrows in a patient with Meige syndrome.

Abstract

PURPOSE:

To describe a patient with Meige syndrome in whom we observed the coexistence of hereditary lymphedema of the lower legs, conjunctival edema and alopecia of the lateral third of the eyebrows.

METHODS:

Case report.

RESULTS:

Histological examination of the conjunctival and skin specimens showed dermal edema and a slight reduction in the number of severely ectatic lymphatics in the reticular dermis. The vessel were identified as lymphatics on the basis of immunohistochemical evidence of discontinuity and/or absence of basement membrane.

CONCLUSIONS:

Clinical and histological findings suggest that the etiopathogenesis of the edema in Meige syndrome is related to a structural ectatic defect of lymphatics. This anomaly seems to involve both skin and other sites, such as conjunctival mucosa.

• Authors: P Rubegni, M Fimiani, G M Tosi, G De Aloe, C Miracco, L Andreassi
• Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (Graefes Arch Clin Exp Ophthalmol) Vol. 238 Issue 1 Pg. 98-100 (Jan 2000) ISSN: 0721-832X [Print] Germany
• PMID: 10664061 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Alopecia (complications, pathology)
• Biopsy
• Conjunctival Diseases (complications, pathology)
• Edema (complications, pathology)
• Eyebrows
• Humans
• Lymphatic System (diagnostic imaging, pathology)
• Male
• Meige Syndrome (complications, diagnostic imaging, pathology)
• Ultrasonography