Abstract | BACKGROUND: Over 2000 protein kinases regulate cellular functions. Screening for inhibitors of some of these kinases has already yielded some potent and selective compounds with promising potential for the treatment of human diseases. RESULTS: CONCLUSIONS:
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Authors | L Meijer, A M Thunnissen, A W White, M Garnier, M Nikolic, L H Tsai, J Walter, K E Cleverley, P C Salinas, Y Z Wu, J Biernat, E M Mandelkow, S H Kim, G R Pettit |
Journal | Chemistry & biology
(Chem Biol)
Vol. 7
Issue 1
Pg. 51-63
(Jan 2000)
ISSN: 1074-5521 [Print] United States |
PMID | 10662688
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Azepines
- Microtubule-Associated Proteins
- Protein Kinase Inhibitors
- Pyrroles
- microtubule-associated protein 1B
- tau Proteins
- Adenosine Triphosphate
- hymenialdisine
- Protein Kinases
- Glycogen Synthase Kinases
- Casein Kinases
- Calcium-Calmodulin-Dependent Protein Kinases
- Cyclin-Dependent Kinases
- Glycogen Synthase Kinase 3
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Topics |
- Adenosine Triphosphate
(antagonists & inhibitors)
- Animals
- Azepines
(pharmacology)
- Calcium-Calmodulin-Dependent Protein Kinases
(antagonists & inhibitors, chemistry)
- Casein Kinases
- Cerebellum
(cytology, drug effects, metabolism)
- Crystallization
- Crystallography, X-Ray
- Cyclin-Dependent Kinases
(antagonists & inhibitors)
- Glycogen Synthase Kinase 3
- Glycogen Synthase Kinases
- Microtubule-Associated Proteins
(metabolism)
- Molecular Conformation
- Neurons
(drug effects, enzymology, metabolism)
- Phosphorylation
- Porifera
(chemistry)
- Protein Kinase Inhibitors
- Protein Kinases
(chemistry)
- Pyrroles
(pharmacology)
- tau Proteins
(metabolism)
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