Association of sex hormone-binding globulin and insulin resistance among Japanese-American subjects.

• Abstract: An association between sex hormone-binding globulin (SHBG) and insulin resistance expressed by the homeostasis model (HOMA-R), and the significance of both variables as risk factors for the development of type 2 diabetes were investigated in 483 Japanese-American subjects. The serum SHBG level was significantly higher in women (68.7 nmol/l) than in men (45.1 nmol/l). This difference was also significant independently of age, body mass index (BMI), waist to hip ratio (WHR), and HOMA-R. When multiple regression analysis was performed after adjustment for age and BMI, SHBG was not correlated with HOMA-R in men. In women, SHBG was not significantly correlated with HOMA-R after adjustment for age, BMI, and WHR. In a 3-year prospective analysis, HOMA-R was significantly higher in converters to type 2 diabetes than non-converters in both men and women which was independent of age, BMI and WHR. However, after adjusting these variables, SHBG was not a significant risk factor either in men or women. These results indicate that SHBG might be related to insulin resistance secondarily via BMI and/or WHR in both men and women among Japanese-Americans. HOMA-R is a useful index for both men and women as a risk factor of type 2 diabetes when only fasting blood samples can be obtained.
• Authors: M Okubo, M Tokui, G Egusa, M Yamakido (Affiliation: Second Department of Internal AMedicine, Hiroshima University School of Medicine, Japan. ohkubo at mcai.med.hiroshima-u.ac.jp)
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 47 Issue 1 Pg. 71-5 (Jan 2000) ISSN: 0168-8227 [Print] IRELAND
• PMID: 10660223 (Publication Type: Journal Article)

Chemical References

• Sex Hormone-Binding Globulin

Topics

• Aged
• Asian Americans
• Diabetes Mellitus, Type 2 (ethnology)
• Disease Susceptibility
• Female
• Homeostasis
• Humans
• Insulin Resistance
• Japan (ethnology)
• Male
• Middle Aged
• Prospective Studies
• Sex Hormone-Binding Globulin (analysis)
• United States