Efficacy of high dose interferon--alpha treatment of chronic hepatitis B.

Abstract

Fifteen consecutive Hepatitis B virus chronic hepatitis patients were treated with interferon alfa-2B 10 mu tiw for 5-6 months. All patients could tolerate the side effects without serious complications throughout the treatment period. Overall, 12 cases had normalization of ALT (80%), 7 cases had loss of HbeAg with appearance of anti-Hbe (58.33%) and 2 cases had loss of HbsAg with the presence of antiHBs (13.33%). The response usually associated with improvement in histology and decrease in viral load. These results seemed to be better than other studies with a lower dose. Further study with more patients should be done in the future.

• Authors: S Techapaitoon
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 82 Issue 11 Pg. 1118-26 (Nov 1999) ISSN: 0125-2208 [Print] Thailand
• PMID: 10659547 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Interferon alpha-2
• Interferon-alpha
• Recombinant Proteins

Topics

• Adult
• Antiviral Agents (administration & dosage)
• Female
• Hepatitis B, Chronic (drug therapy)
• Humans
• Interferon alpha-2
• Interferon-alpha (administration & dosage)
• Male
• Prospective Studies
• Recombinant Proteins
• Treatment Outcome