Abstract |
Glibenclamide-induced cardiac hemodynamic changes before and after ischemia have been frequently studied. In general a Langendorff buffer perfused heart model was used to examine these effects. However these models used protein-free buffer perfusates. To improve clinical relevance and thereby enhance extrapolation to the in vivo condition we studied the effects of glibenclamide on cardiac hemodynamics using a working, erythrocyte perfused, rat heart model, where the perfusate was enriched with albumin. The results show a dose-dependent decline in CBF in normoxia and at the end of reperfusion (after an ischemic period) with glibenclamide treatment compared to control. Cardiac functional recovery improved with 1 and 4 mumol.L-1 glibenclamide concentrations. From this study it seems that there is a marked decrease in CBF but this did not result in impaired myocardial function after a period of ischemia, so it appears that there are no startling side effects of glibenclamide in the ischemic rat heart.
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Authors | R J Legtenberg, R J Houston, P Smits, B Oeseburg |
Journal | Advances in experimental medicine and biology
(Adv Exp Med Biol)
Vol. 471
Pg. 257-63
( 1999)
ISSN: 0065-2598 [Print] United States |
PMID | 10659155
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hypoglycemic Agents
- Potassium Channel Blockers
- Glyburide
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Topics |
- Animals
- Coronary Vessels
(drug effects, physiopathology)
- Erythrocytes
- Glyburide
(pharmacology)
- Heart
(drug effects, physiopathology)
- Hemodynamics
(drug effects)
- Hypoglycemic Agents
(pharmacology)
- Male
- Potassium Channel Blockers
- Rats
- Rats, Wistar
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