| Abstract | BACKGROUND: In this study the circadian skin flux pattern was evaluated in 10 normal reference subjects and in 35 patients (mean age 68 +/- 11) subdivided in groups (10 with intermittent claudication (200-400 m of walking distance), 10 diabetics with claudication, 7 patients with rest pain and 8 with localised gangrene). METHODS: A laser Doppler flowmeter was used to monitor skin flux for 24 hours. In patients with intermittent claudication the circadian pattern was comparable to normal subjects. In diabetics the daily curve showed several irregular peaks mostly dissociated from activity or rest. RESULTS: In patients with critical ischaemia severe alterations of the circadian pattern were observed (the daily curve was flattened and dissociated from activity or rest) particularly in gangrene. PGE1 alpha-ciclodestrina treatment (60 micrograms/day) partially restored the circadian pattern and increased the average values of the 24-hour curve. In rest pain and gangrene the infusion of PGE1 alpha-ciclodestrina in the late evening increased the average night flux (which tended to fall to very low levels causing pain) and prevented or abolished night rest pain. |
| Authors | G Laurora, G Belcaro
(Affiliation: Angiology and Vasc. Surgery, Clinical Trials Unit, Pierangeli Clinic, Pescara.)
|
| Journal | Minerva cardioangiologica
(Minerva Cardioangiol)
Vol. 46
Issue 10 Suppl 1
Pg. 45-9
(Oct 1998)
ISSN: 0026-4725 ITALY |
| Vernacular Title | Variazioni circadiane di flusso cutaneo in soggetti normali ed in pazienti con arteriopatie periferiche. Effetto della PGE1 alpha-ciclodestrina. |
| PMID | 10658444
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Cyclodextrins
- Vasodilator Agents
- Alprostadil
|
| Topics |
- Alprostadil
(pharmacology, therapeutic use)
- Blood Circulation
- Circadian Rhythm
- Cyclodextrins
(pharmacology, therapeutic use)
- Foot
(blood supply)
- Humans
- Intermittent Claudication
(drug therapy, physiopathology)
- Laser-Doppler Flowmetry
- Peripheral Vascular Diseases
(drug therapy, physiopathology)
- Skin
(blood supply)
- Vasodilator Agents
(therapeutic use)
|
