| Abstract | The efficacy and tolerability profiles of nimesulide and diclofenac were evaluated in 180 patients suffering from various degenerative joint diseases. The clinical evaluations were performed at 0, 2 and 4 weeks. Nimesulide (100 mg) tablets were administered twice daily and diclofenac (50 mg) tablets were administered thrice daily. The principal efficacy parameters were the improvement in pain assessed through verbal scoring. Evaluation of tolerance was also established through similar method. Final judgment on efficacy was made by the physician. In all evaluations nimesulide showed improved efficacy parameters over diclofenac. |
| Authors | I Zgradie
(Affiliation: Clinic of Rheumatology and Clinical Immunology, Military Medical Academy, Belgrade, Yugoslavia.)
|
| Journal | Journal of the Indian Medical Association
(J Indian Med Assoc)
Vol. 97
Issue 4
Pg. 119-23
(Apr 1999)
ISSN: 0019-5847 INDIA |
| PMID | 10652894
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
|
| Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Sulfonamides
- Diclofenac
- nimesulide
|
| Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents, Non-Steroidal
(adverse effects, therapeutic use)
- Diclofenac
(adverse effects, therapeutic use)
- Double-Blind Method
- Female
- Humans
- Lumbosacral Region
- Male
- Middle Aged
- Osteoarthritis
(drug therapy)
- Osteoarthritis, Hip
(drug therapy)
- Osteoarthritis, Knee
(drug therapy)
- Pain
(diagnosis, drug therapy)
- Spinal Diseases
(drug therapy)
- Sulfonamides
(adverse effects, therapeutic use)
- Treatment Outcome
|
