[Biological activity and structure of antitumor compounds from Plantago media L].

Abstract

Tyrosine kinase inhibition and tumor growth inhibition activity of verbascoside and homoplantaginin are described. Both molecules proved to be equally significant inhibitors of isolated EGF-R tyrosine kinases, nevertheless their in vitro antiproliferative activity was variable in cellular assays. Their different inhibitory efficacies could be interpreted on the basis of conformational analysis and lipophilicity evaluation.

• Authors: M Kunvári, C Páska, M László, L Orfi, I Kövesdi, D Eros, G Bökönyi, G Kéri, I Gyurján
• Journal: Acta pharmaceutica Hungarica (Acta Pharm Hung) Vol. 69 Issue 5 Pg. 232-9 (Nov 1999) ISSN: 0001-6659 [Print] Hungary
• Vernacular Title: Plantago media L antitumor hatóanyagainak szerkezete és biológiai aktivitása.
• PMID: 10652790 (Publication Type: Journal Article)

Chemical References

• 6-methoxy-4',5-dihydroxyflavone-7-O-glucoside
• Antineoplastic Agents, Phytogenic
• Flavonoids
• Glucosides
• Phenols
• acteoside
• ErbB Receptors

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Cell Division (drug effects)
• Cell Survival (drug effects)
• ErbB Receptors (drug effects)
• Flavonoids (chemistry, isolation & purification, pharmacology)
• Glucosides (chemistry, isolation & purification, pharmacology)
• Humans
• Molecular Conformation
• Phenols
• Plantago
• Plants, Medicinal
• Tumor Cells, Cultured