Abstract | BACKGROUND: METHODS AND RESULTS: Levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), triglyceride, lipoprotein(a), RLP-C, uric acid, blood glucose, tissue plasminogen activator, tissue plasminogen activator inhibitor type 1, antithrombin III, and protein C were measured in 208 patients who underwent diagnostic coronary angiograms. Of these 208 patients, 57 were hypercholesterolemic (> or =220 mg/dL) and 151 were normocholesterolemic. HDL-C showed significant differences between patients with and those without angiographically determined coronary artery stenosis in both hypercholesterolemic and normocholesterolemic patients (P =.0025 and P =.0003, respectively). Both RLP-C and uric acid showed significant differences only in the normocholesterolemic subgroup (P =.0006 and P =.0060, respectively). This difference in uric acid was not significant by multivariable analysis. The ratio of RLP-C/HDL-C was demonstrated to be highly significantly (P <.0001) associated with coronary artery stenosis in patients with normal total cholesterol, whereas there was no statistically significant association in the hypercholesterolemic patient subgroup. CONCLUSIONS: Our current study disclosed that RLP-C levels are strongly associated with coronary artery disease, especially in patients with normal total cholesterol levels. Moreover, RLP-C/HDL-C ratio may be even more significantly associated with the presence of coronary artery stenosis in normocholesterolemic patients.
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Authors | H Masuoka, S Kamei, H Wagayama, M Ozaki, A Kawasaki, T Tanaka, M Kitamura, S Katoh, U Shintani, M Misaki, M Sugawa, M Ito, T Nakano |
Journal | American heart journal
(Am Heart J)
Vol. 139
Issue 2 Pt 1
Pg. 305-10
(Feb 2000)
ISSN: 0002-8703 [Print] United States |
PMID | 10650304
(Publication Type: Journal Article)
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Chemical References |
- Cholesterol, HDL
- Uric Acid
- Cholesterol
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Cholesterol
(blood)
- Cholesterol, HDL
- Coronary Disease
(blood)
- Fibrinolysis
- Humans
- Hypercholesterolemia
(blood)
- Middle Aged
- Retrospective Studies
- Uric Acid
(blood)
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