A new depsipeptide from the sacoglossan mollusk Elysia ornata and the green alga Bryopsis species.

Abstract

A new cyclic depsipeptide, kahalalide O (1), was isolated from the sacoglossan Elysia ornata and its algal diet Bryopsis sp. The structure was elucidated primarily by NMR and MS spectral methods, and the stereochemistry of the amino acid residues was determined by chiral HPLC and Marfey analyses. Unlike the related metabolite kahalalide F, which is in development as a potential anticancer agent, kahalalide O (1) was inactive in arresting the growth of P-388, A549, HT29, and MEL28 cancer cell lines in vitro.

• Authors: F D Horgen, D B delos Santos, G Goetz, B Sakamoto, Y Kan, H Nagai, P J Scheuer
• Journal: Journal of natural products (J Nat Prod) Vol. 63 Issue 1 Pg. 152-4 (Jan 2000) ISSN: 0163-3864 [Print] United States
• PMID: 10650101 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Depsipeptides
• Peptides, Cyclic
• kahalalide O

Topics

• Animals
• Chlorophyta (chemistry)
• Chromatography, High Pressure Liquid
• Depsipeptides
• Drug Screening Assays, Antitumor
• Magnetic Resonance Spectroscopy
• Mollusca (chemistry)
• Peptides, Cyclic (chemistry, isolation & purification, pharmacology)
• Protein Conformation
• Tumor Cells, Cultured