A multicenter, placebo-controlled pilot study of intravenous immune globulin treatment of antiphospholipid syndrome during pregnancy. The Pregnancy Loss Study Group.
Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: Sixteen women were enrolled during a 2-year period; 7 received intravenous immune globulin and 9 were given placebo. The groups were similar with respect to age, gravidity, number of previous pregnancy losses, and gestational age at the initiation of treatment. Obstetric outcomes were excellent in both groups, with all women being delivered of live-born infants after 32 weeks' gestation. The rates of antepartum complications such as preeclampsia, fetal growth restriction, and placental insufficiency (as manifested by fetal growth restriction or fetal distress) were similar between the 2 groups. Gestational age at delivery ( intravenous immune globulin group, 34.6 +/- 1.1 weeks; placebo group, 36.7 +/- 2.1 weeks) and birth weights ( intravenous immune globulin group, 2249.7 +/- 186.1 g; placebo group; 2604.4 +/- 868.9 g) were similar between the 2 groups. There were fewer cases of fetal growth restriction ( intravenous immune globulin group, 0%; placebo group, 33%) and neonatal intensive care unit admission ( intravenous immune globulin group, 20%; placebo group, 44%) among the infants in the intravenous immune globulin group than those in the placebo group, but these differences were not significant. CONCLUSION:
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Authors | D W Branch, A M Peaceman, M Druzin, R K Silver, Y El-Sayed, R M Silver, M S Esplin, J Spinnato, J Harger |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 182
Issue 1 Pt 1
Pg. 122-7
(Jan 2000)
ISSN: 0002-9378 [Print] United States |
PMID | 10649166
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunoglobulins, Intravenous
- Placebos
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Topics |
- Adult
- Antiphospholipid Syndrome
(complications, drug therapy)
- Double-Blind Method
- Female
- Gestational Age
- HELLP Syndrome
(complications)
- Humans
- Immunoglobulins, Intravenous
(therapeutic use)
- Infant, Newborn
- Pilot Projects
- Placebos
- Pre-Eclampsia
(complications)
- Pregnancy
- Pregnancy Complications
- Pregnancy Outcome
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