Abstract |
An increased intake of soluble fiber and soy protein may improve the blood lipid profile. To assess any additional benefit on serum lipids of providing soy protein and soluble-fiber foods to hyperlipidemic subjects already consuming low-fat, low-cholesterol therapeutic diets, 20 hyperlipidemic men and postmenopausal women completed 8-week test and control dietary treatments in a randomized crossover design as part of an ad libitum National Cholesterol Education Program (NCEP) step 2 therapeutic diet (<7% saturated fat and <200 mg/d cholesterol). During the test phase, foods high in soy, other vegetable proteins, and soluble fiber were provided. During the control phase, low-fat dairy and low-soluble-fiber foods were provided. Fasting blood lipid and apolipoprotein levels were measured at 4 and 8 weeks of each phase. On the test diet, 12 +/- 2 g/d soy protein was selected from the foods chosen. Direct comparison of test and control treatments indicated an elevated high-density lipoprotein (HDL) cholesterol concentration on the test diet (6.4% +/- 2.4%, P = .013) and a significantly reduced total to HDL cholesterol ratio (-5.9% +/- 2.3%, P = .020). The proportion of conjugated dienes in the low-density lipoprotein (LDL) cholesterol fraction was significantly reduced (8.5% +/- 3.3%, P = .020) as a marker of oxidized LDL. A combination of acceptable amounts of soy, vegetable protein, and soluble-fiber foods as part of a conventional low-fat, low-cholesterol therapeutic diet is effective in further reducing serum lipid risk factors for cardiovascular disease.
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Authors | D J Jenkins, C W Kendall, E Vidgen, C C Mehling, T Parker, H Seyler, D Faulkner, M Garsetti, L C Griffin, S Agarwal, A V Rao, S C Cunnane, M A Ryan, P W Connelly, L A Leiter, V Vuksan, R Josse |
Journal | Metabolism: clinical and experimental
(Metabolism)
Vol. 49
Issue 1
Pg. 67-72
(Jan 2000)
ISSN: 0026-0495 [Print] United States |
PMID | 10647066
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dietary Fiber
- Lipids
- Lipoproteins
- Lipoproteins, LDL
- Soybean Proteins
- Triglycerides
- oxidized low density lipoprotein
- Cholesterol
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Topics |
- Adult
- Aged
- Cholesterol
(blood)
- Cross-Over Studies
- Diet, Fat-Restricted
- Dietary Fiber
(administration & dosage)
- Dietary Supplements
- Female
- Humans
- Hyperlipidemias
(blood)
- Lipids
(blood)
- Lipoproteins
(blood)
- Lipoproteins, LDL
(blood)
- Male
- Middle Aged
- Postmenopause
- Soybean Proteins
(administration & dosage)
- Triglycerides
(blood)
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