5-HT5a receptors in the carotid body chemoreception pathway of rat.

Abstract

By using a specific antibody, 5-HT5a receptor-like immunoreactivity was revealed in the chemoreceptive, oxygen sensitive, carotid body (CB) type I cells, and neurons of the petrosal ganglion (PG) and the superior cervical ganglion (SCG) in rat. mRNA encoding for the 5-HTa receptor was also detected in these tissues by RT-PCR, and confirmed with DNA sequencing. The present study provides direct evidence that 5-HT5a receptors are expressed in the CB, PG and SCG, which all likely play fundamental roles in arterial chemoreception.

• Authors: Z Y Wang, I M Keith, M J Beckman, M S Brownfield, E H Vidruk, G E Bisgard
• Journal: Neuroscience letters (Neurosci Lett) Vol. 278 Issue 1-2 Pg. 9-12 (Jan 07 2000) ISSN: 0304-3940 [Print] Ireland
• PMID: 10643788 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Nerve Tissue Proteins
• RNA, Messenger
• Receptors, Serotonin
• serotonin 5 receptor
• Serotonin

Topics

• Afferent Pathways (chemistry)
• Animals
• Carotid Body (chemistry, cytology)
• Cell Hypoxia
• Chemoreceptor Cells (chemistry)
• Ganglia, Sensory (chemistry)
• Glossopharyngeal Nerve (chemistry, physiology)
• Male
• Nerve Tissue Proteins (analysis, biosynthesis, genetics)
• RNA, Messenger (analysis)
• Rats
• Rats, Sprague-Dawley
• Receptors, Serotonin (analysis, biosynthesis, genetics)
• Reverse Transcriptase Polymerase Chain Reaction
• Serotonin (physiology)
• Superior Cervical Ganglion (chemistry)