Abstract |
The indirect susceptibility test results on L-J medium for tubercle bacilli against streptomycin, isoniazid and rifampicin were read at the end of 2 wk and compared with the results at 4 wk. It was found that drug resistance could be correctly predicted in over 70 per cent of cultures including multi-drug resistant tuberculosis (MDR TB) strains at the end of 2 wk. The susceptibility to para-nitrobenzoic acid (PNB) read at 2 wk was able to distinguish non-tuberculous mycobacteria from Mycobacterium tuberculosis cultures. The early detection of resistance by this procedure requires only minimum inputs, and can benefit the majority of patients harbouring drug resistant tubercle bacilli.
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Authors | S Mathew, A Narayanan, R Segaran, C N Paramasivan |
Journal | The Indian journal of medical research
(Indian J Med Res)
Vol. 109
Pg. 167-9
(May 1999)
ISSN: 0971-5916 [Print] India |
PMID | 10643140
(Publication Type: Journal Article)
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Chemical References |
- Antitubercular Agents
- Nitrobenzoates
- 4-nitrobenzoic acid
- Isoniazid
- Rifampin
- Streptomycin
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Topics |
- Antitubercular Agents
(pharmacology)
- Drug Resistance, Microbial
- Isoniazid
(pharmacology)
- Microbial Sensitivity Tests
- Mycobacterium tuberculosis
(drug effects)
- Nitrobenzoates
(pharmacology)
- Rifampin
(pharmacology)
- Streptomycin
(pharmacology)
- Tuberculosis, Multidrug-Resistant
(microbiology)
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