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Early results from indirect drug susceptibility test for tubercle bacilli.

Abstract
The indirect susceptibility test results on L-J medium for tubercle bacilli against streptomycin, isoniazid and rifampicin were read at the end of 2 wk and compared with the results at 4 wk. It was found that drug resistance could be correctly predicted in over 70 per cent of cultures including multi-drug resistant tuberculosis (MDR TB) strains at the end of 2 wk. The susceptibility to para-nitrobenzoic acid (PNB) read at 2 wk was able to distinguish non-tuberculous mycobacteria from Mycobacterium tuberculosis cultures. The early detection of resistance by this procedure requires only minimum inputs, and can benefit the majority of patients harbouring drug resistant tubercle bacilli.
AuthorsS Mathew, A Narayanan, R Segaran, C N Paramasivan
JournalThe Indian journal of medical research (Indian J Med Res) Vol. 109 Pg. 167-9 (May 1999) ISSN: 0971-5916 [Print] India
PMID10643140 (Publication Type: Journal Article)
Chemical References
  • Antitubercular Agents
  • Nitrobenzoates
  • 4-nitrobenzoic acid
  • Isoniazid
  • Rifampin
  • Streptomycin
Topics
  • Antitubercular Agents (pharmacology)
  • Drug Resistance, Microbial
  • Isoniazid (pharmacology)
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis (drug effects)
  • Nitrobenzoates (pharmacology)
  • Rifampin (pharmacology)
  • Streptomycin (pharmacology)
  • Tuberculosis, Multidrug-Resistant (microbiology)

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