Anesthesia of wood bison with medetomidine-zolazepam/tiletamine and xylazine-zolazepam/tiletamine combinations.

Abstract

This study was designed to evaluate 2 combinations for immobilization of bison. Seven wood bison received 1.5 mg/kg body weight (BW) of xylazine HCl + 1.5 mg/kg BW of zolazepam HCl and 1.5 mg/kg BW of tiletamine HCl on one occasion. The bison received 60 micrograms/kg BW of medetomidine HCl + 0.6 mg/kg BW of zolazepam HCl and 0.6 mg/kg BW of tiletamine HCL on another occasion. Xylazine was antagonized with 3 mg/kg BW of tolazoline HCl and medetomidine HCl was antagonized with 180 micrograms/kg (BW) of atipamezole HCl. Temporal characteristics of immobilization and physiological effects (acid-base status, thermoregulatory, cardiovascular, and respiratory effects) of the drug combinations were compared. Induction was significantly faster with xylazine HCl-zolazepam HCl/tiletamine HCl. Recovery following antagonist administration was significantly faster with medetomidine HCl-zolazepam HCl/tiletamine HCl. The average drug volumes required were 7.00 mL of xylazine HCl-zolazepam HCl/tiletamine HCL and 2.78 mL of medetomidine HCl-zolazepam HCl/tiletamine HCl. Hypoxemia, hypercarbia, and rumenal tympany were the major adverse effects with both drug combinations.

• Authors: N A Caulkett, M R Cattet, S Cantwell, N Cool, W Olsen
• Journal: The Canadian veterinary journal = La revue veterinaire canadienne (Can Vet J) Vol. 41 Issue 1 Pg. 49-53 (Jan 2000) ISSN: 0008-5286 [Print] Canada
• PMID: 10642872 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic alpha-Agonists
• Analgesics, Non-Narcotic
• Anesthetics, Dissociative
• Anti-Anxiety Agents
• Benzodiazepines
• Xylazine
• Tiletamine
• Zolazepam
• Medetomidine

Topics

• Adrenergic alpha-Agonists (therapeutic use)
• Analgesics, Non-Narcotic (administration & dosage, therapeutic use)
• Anesthesia (methods, veterinary)
• Anesthetics, Dissociative (administration & dosage, therapeutic use)
• Animals
• Animals, Domestic
• Anti-Anxiety Agents (administration & dosage, therapeutic use)
• Benzodiazepines
• Bison
• Drug Therapy, Combination
• Male
• Medetomidine (administration & dosage, therapeutic use)
• Tiletamine (administration & dosage, therapeutic use)
• Veterinary Medicine (methods)
• Xylazine (administration & dosage, therapeutic use)
• Zolazepam (administration & dosage, therapeutic use)