Botulinum toxin A as treatment for drooling saliva in PD.

Abstract

The authors evaluated intraparotid injections of botulinum toxin A in reducing salivary secretions and drooling in nine patients with PD. There was a marked objective reduction in secretion, and two thirds of the patients had subjective improvement in drooling. No side effects were observed. The authors conclude that botulinum toxin A promises to be a simple and effective treatment for the common problem of drooling saliva in chronic neurologic disease.

• Authors: P K Pal, D B Calne, S Calne, J K Tsui
• Journal: Neurology (Neurology) Vol. 54 Issue 1 Pg. 244-7 (Jan 11 2000) ISSN: 0028-3878 [Print] United States
• PMID: 10636161 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Botulinum Toxins, Type A

Topics

• Aged
• Aged, 80 and over
• Botulinum Toxins, Type A (therapeutic use)
• Female
• Humans
• Injections
• Male
• Middle Aged
• Parkinson Disease (complications)
• Parotid Gland (drug effects, metabolism)
• Saliva (drug effects, metabolism)
• Sialorrhea (drug therapy, etiology)
• Treatment Outcome