Abstract | BACKGROUND: OBJECTIVE: To determine whether women with inherited clotting defects who use oral contraceptives develop venous thrombosis at an earlier stage than do those without inherited clotting defects. METHODS: RESULTS: Risk of developing deep vein thrombosis was greatest in the first 6 months and the first year of oral contraceptive use. Compared with prolonged use, the risk of developing deep vein thrombosis was 3-fold higher in the first 6 months of use (95% confidence interval [CI], 0.6-14.8) and 2-fold higher in the first year of use (95% CI, 0.6-6.1). Patients who developed venous thrombosis in the early periods of use were more often thrombophilic. Among women with thrombophilia, the risk of developing deep vein thrombosis during the first 6 months of oral contraceptive use (compared with prolonged use) was increased 19-fold (95% CI, 1.9-175.7), and in the first year of use, it was increased 11-fold (95% CI, 2.1-57.3). CONCLUSIONS:
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Authors | K W Bloemenkamp, F R Rosendaal, F M Helmerhorst, J P Vandenbroucke |
Journal | Archives of internal medicine
(Arch Intern Med)
Vol. 160
Issue 1
Pg. 49-52
(Jan 10 2000)
ISSN: 0003-9926 [Print] United States |
PMID | 10632304
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Blood Coagulation Disorders
(genetics)
- Case-Control Studies
- Contraceptives, Oral
(adverse effects)
- Female
- Humans
- Middle Aged
- Risk
- Risk Factors
- Time Factors
- Venous Thrombosis
(chemically induced, genetics)
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