Chlorpropamide toxicity with survival despite 27-day hypoglycemia.

Abstract

CASE REPORT:

In the past 5 years at our institution, 12 cases involving the ingestion of chlorpropamide 3-15 g were fatal. We report a 23-year-old woman with an estimated ingestion of chlorpropamide 5-10 g. Initial cardiovascular collapse, attributed to the blockade of potassium channel transport, responded to intensive support including 3 days of cardiac pacing. Urinary excretion of chlorpropamide and hypoglycemia persisted until day 27. The toxic mechanisms and high risk of chlorpropamide are summarized. A fatal therapeutic dose ratio as low as 4:1 has made this antidiabetic agent obsolete.

• Authors: K Ciechanowski, K S Borowiak, B A Potocka, M Nowacka, G Dutkiewicz
• Journal: Journal of toxicology. Clinical toxicology (J Toxicol Clin Toxicol) Vol. 37 Issue 7 Pg. 869-71 ( 1999) ISSN: 0731-3810 [Print] United States
• PMID: 10630272 (Publication Type: Case Reports, Journal Article)

Chemical References

• Hypoglycemic Agents
• Chlorpropamide

Topics

• Adult
• Chlorpropamide (poisoning, urine)
• Electrocardiography
• Female
• Humans
• Hypoglycemia (blood, chemically induced)
• Hypoglycemic Agents (poisoning, urine)
• Respiration, Artificial
• Shock (chemically induced, physiopathology)
• Suicide, Attempted