Inhibition of chemical carcinogenesis by Psoralea corylifolia seeds.

Abstract

Psoralea corylifolia L. (Fabaceae) seeds are extensively used in Ayurvedic medicine. Topical application of 100 mg/kg body weight of the active fraction (AF) of P. corylifolia seeds inhibited the growth and delayed the onset of papilloma formation in mice, initiated with 7,12-dimethyl benz(a) anthracene and promoted using croton oil. The AF at the same dose, when administered orally, inhibited the growth of subcutaneously injected 20-methylcholanthrene (MCA)--induced soft tissue fibrosarcomas significantly. The AF has been shown by gas chromatography analysis to be composed of a mixture of glycerides of fatty acids.

• Authors: P G Latha, K R Panikkar
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 68 Issue 1-3 Pg. 295-8 (Dec 15 1999) ISSN: 0378-8741 [Print] Ireland
• PMID: 10624891 (Publication Type: Journal Article)

Chemical References

• Anticarcinogenic Agents
• Antigens, Tumor-Associated, Carbohydrate
• Carcinogens
• Plant Extracts
• mucinous carcinoma-associated antigen
• 9,10-Dimethyl-1,2-benzanthracene

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Administration, Topical
• Animals
• Anticarcinogenic Agents (isolation & purification, therapeutic use)
• Antigens, Tumor-Associated, Carbohydrate
• Carcinogens
• Male
• Medicine, Ayurvedic
• Mice
• Papilloma (chemically induced, prevention & control)
• Plant Extracts (therapeutic use, toxicity)
• Seeds (chemistry)
• Time Factors