Abstract | BACKGROUND: METHODS: We immunoquantified PLC beta 1, gamma 1 and delta 1 in the left prefrontal cortex and superior temporal cortex, nucleus accumbens and amygdala, and in the right superior temporal cortex of postmortem brains obtained from a total of 19 patients with schizophrenia and a total of 27 controls. RESULTS:
PLC beta 1 immunoreactivities were increased in the particulate fraction from the prefrontal cortex (by 64%), although they were decreased in the particulate fraction from the left superior temporal cortex (by 28%), as compared with the values in controls. There was no difference in PLC beta 1 immunoreactivities in the nucleus accumbens, the amygdala or the right superior temporal cortex between schizophrenic patients and controls. PLC gamma 1 and delta 1 immunoreactivities did not differ between the two groups in any of the regions studied. CONCLUSIONS: Changes in PLC beta 1 immunoreactivities in the prefrontal and superior temporal cortex of patients with schizophrenia may reflect abnormalities in neurotransmissions via receptors that are coupled with the Gq alpha- PLC beta 1 cascade.
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Authors | X H Lin, N Kitamura, T Hashimoto, O Shirakawa, K Maeda |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 46
Issue 12
Pg. 1665-71
(Dec 15 1999)
ISSN: 0006-3223 [Print] United States |
PMID | 10624548
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Phosphatidylinositols
- Type C Phospholipases
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Topics |
- Amygdala
(enzymology)
- Blotting, Western
- Case-Control Studies
- Chronic Disease
- Female
- Humans
- Male
- Middle Aged
- Nucleus Accumbens
(enzymology)
- Phosphatidylinositols
(metabolism)
- Prefrontal Cortex
(enzymology)
- Schizophrenia
(enzymology)
- Temporal Lobe
(enzymology)
- Type C Phospholipases
(metabolism)
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