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Opposite changes in phosphoinositide-specific phospholipase C immunoreactivity in the left prefrontal and superior temporal cortex of patients with chronic schizophrenia.

AbstractBACKGROUND:
Abnormalities in types of neurotransmitter signaling that are coupled with phosphoinositide-specific phospholipase C (PLC) have previously been reported in brains from patients with schizophrenia. PLC, a main component of this pathway, may be affected in schizophrenia.
METHODS:
We immunoquantified PLC beta 1, gamma 1 and delta 1 in the left prefrontal cortex and superior temporal cortex, nucleus accumbens and amygdala, and in the right superior temporal cortex of postmortem brains obtained from a total of 19 patients with schizophrenia and a total of 27 controls.
RESULTS:
PLC beta 1 immunoreactivities were increased in the particulate fraction from the prefrontal cortex (by 64%), although they were decreased in the particulate fraction from the left superior temporal cortex (by 28%), as compared with the values in controls. There was no difference in PLC beta 1 immunoreactivities in the nucleus accumbens, the amygdala or the right superior temporal cortex between schizophrenic patients and controls. PLC gamma 1 and delta 1 immunoreactivities did not differ between the two groups in any of the regions studied.
CONCLUSIONS:
Changes in PLC beta 1 immunoreactivities in the prefrontal and superior temporal cortex of patients with schizophrenia may reflect abnormalities in neurotransmissions via receptors that are coupled with the Gq alpha-PLC beta 1 cascade.
AuthorsX H Lin, N Kitamura, T Hashimoto, O Shirakawa, K Maeda
JournalBiological psychiatry (Biol Psychiatry) Vol. 46 Issue 12 Pg. 1665-71 (Dec 15 1999) ISSN: 0006-3223 [Print] United States
PMID10624548 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Phosphatidylinositols
  • Type C Phospholipases
Topics
  • Amygdala (enzymology)
  • Blotting, Western
  • Case-Control Studies
  • Chronic Disease
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nucleus Accumbens (enzymology)
  • Phosphatidylinositols (metabolism)
  • Prefrontal Cortex (enzymology)
  • Schizophrenia (enzymology)
  • Temporal Lobe (enzymology)
  • Type C Phospholipases (metabolism)

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