The effect of nipradilol on the isoproterenol-induced depression of contractions in the cat soleus muscle.

Abstract

The effect of nipradilol on the isoproterelol-induced depression of contractions of the soleus muscle of the anesthetized cats was studied. Isoproterenol (0.3 microg/kg) injected intravenously decreased the tension and degree of fusion of incomplete tetanic contractions of the soleus muscle of the anesthetized cats. The effect of isoproterenol was blocked by nipradilol (> or = 3 microg/kg), desnitro-nipradilol (> or = 10 microg/kg) and propranolol (> or = 10 microg/kg), but not by nitroglycerin (10-100 microg/kg). Nipradilol (30 microg/kg) and desnitronipradilol (300 microg/kg) almost completely antagonized the depressor effects of isoproterenol. These results coupled with evidence that nipradilol does not penetrate the blood-brain barrier indicate that nipradilol exerts an anti-tremor action by blocking peripheral beta2-adrenoceptors.

• Authors: T Tanaka, N Murata, Y Yamauchi
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 81 Issue 3 Pg. 286-91 (Nov 1999) ISSN: 0021-5198 [Print] Japan
• PMID: 10622217 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-Agonists
• Adrenergic beta-Antagonists
• Propanolamines
• nipradilol
• Isoproterenol

Topics

• Adrenergic beta-Agonists (pharmacology)
• Adrenergic beta-Antagonists (pharmacology)
• Animals
• Cats
• Female
• Isoproterenol (antagonists & inhibitors, pharmacology)
• Male
• Muscle Contraction (drug effects)
• Muscle, Skeletal (drug effects, physiology)
• Propanolamines (pharmacology)