| Abstract | Insulin-like growth factor 1 (IGF1) has been shown to improve renal function in healthy subjects, as well as those with chronic renal failure. To our knowledge, IGF1 has not been shown to be efficacious in patients who were already undergoing dialysis. We present the case of a 70-year-old woman with end-stage renal disease (ESRD) and overt uremic symptoms treated with IGF1 after peritoneal dialysis was discontinued because of complications. There was a significant improvement in her inulin clearance during the course of treatment. The patient remained well and did not require dialytic support for 19 weeks. Although further data are necessary, we believe this case shows that IGF1 may be a short-term alternative to dialysis in patients with ESRD. |
| Authors | A Vijayan, S C Franklin, J A Delmez, S B Miller
(Affiliation: Renal Division, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.)
|
| Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 35
Issue 1
Pg. 150-3
(Jan 2000)
ISSN: 1523-6838 UNITED STATES |
| PMID | 10620558
(Publication Type: Case Reports, Clinical Trial, Journal Article)
|
| Chemical References |
- Insulin-Like Growth Factor I
|
| Topics |
- Aged
- Female
- Humans
- Injections, Subcutaneous
- Insulin-Like Growth Factor I
(administration & dosage)
- Kidney Failure, Chronic
(blood, genetics, therapy)
- Kidney Function Tests
- Peritoneal Dialysis, Continuous Ambulatory
- Polycystic Kidney, Autosomal Dominant
(genetics)
- Treatment Outcome
- Uremia
(blood, genetics, therapy)
|
