Bacteremic pneumonia caused by a single clone of Streptococcus pneumoniae with different optochin susceptibilities.

Abstract

Two isolates of Streptococcus pneumoniae having different optochin susceptibilities were recovered from a blood sample of a 2-year-old boy with community-acquired pneumonia. The two isolates were documented to belong to a single clone on the basis of the isolates' identical serotype (23F), antibiograms by the E-test, random amplified polymorphic DNA patterns generated by arbitrarily primed PCR, pulsed-field gel electrophoresis, and restriction fragment length polymorphism of the penicillin-binding protein genes pbp2b and pbp2x.

• Authors: H Y Tsai, P R Hsueh, L J Teng, P I Lee, L M Huang, C Y Lee, K T Luh
• Journal: Journal of clinical microbiology (J Clin Microbiol) Vol. 38 Issue 1 Pg. 458-9 (Jan 2000) ISSN: 0095-1137 [Print] United States
• PMID: 10618143 (Publication Type: Case Reports, Journal Article)

Chemical References

• ethylhydrocupreine
• Quinine
• Cefazolin
• Cephalexin

Topics

• Bacteremia (drug therapy, microbiology)
• Bacterial Typing Techniques
• Cefazolin (therapeutic use)
• Cephalexin (therapeutic use)
• Child, Preschool
• Clone Cells
• Community-Acquired Infections
• Electrophoresis, Gel, Pulsed-Field
• Humans
• Male
• Microbial Sensitivity Tests
• Pneumonia, Pneumococcal (drug therapy, microbiology)
• Polymerase Chain Reaction
• Polymorphism, Restriction Fragment Length
• Quinine (analogs & derivatives, pharmacology)
• Random Amplified Polymorphic DNA Technique
• Serotyping
• Streptococcus pneumoniae (classification, drug effects)