Specific cell-mediated immunity in fish.

Abstract

This review describes the fish immune system, focusing on specific cell-mediated immunity. Specific in vivo cell-mediated immune responses have been shown by allograft rejection, graft-versus-host reaction (GVHR) and delayed hypersensitivity reaction (DTH). Recent in vitro studies also showed specific cell-mediated cytotoxicity against allogeneic target cells. These in vivo and in vitro experiments strongly suggest the presence of cytotoxic T cells in fishes. Also described are current studies on shark and trout MHC class I polymorphism and function that demonstrate strong similarities between fish and mammals.

• Authors: T Nakanishi, K Aoyagi, C Xia, J M Dijkstra, M Ototake
• Journal: Veterinary immunology and immunopathology (Vet Immunol Immunopathol) Vol. 72 Issue 1-2 Pg. 101-9 (Dec 15 1999) ISSN: 0165-2427 [Print] Netherlands
• PMID: 10614499 (Publication Type: Journal Article, Review)

Topics

• Animals
• Fishes (genetics, immunology)
• Genes, MHC Class I (genetics, immunology)
• Graft Rejection (immunology)
• Graft vs Host Disease (immunology)
• Hypersensitivity, Delayed (immunology)
• Immunity, Cellular (genetics, immunology)
• Oncorhynchus mykiss (genetics, immunology)
• Polymorphism, Genetic (genetics, immunology)
• Sharks (genetics, immunology)