Differences in levels of soluble E-selectin and VCAM-1 in malignant versus non malignant Mediterranean spotted fever.

Abstract

In the present study, we investigated the plasma levels of soluble adhesion molecules E-selectin, P-selectin, intercellular adhesion molecule- (ICAM- ) and vascular cell adhesion molecule-1(VCAM-1) in 24 patients with Mediterranean spotted fever (MSF), 6 of whom with a malignant form. Measurements were performed on blood samples collected before treatment (T1), then twice during treatment (T2 and T3). Before treatment, MSF patients taken as a whole presented elevated levels of sICAM-1 and sVCAM-1 and normal levels of sE-selectin and sP-selectin compared to healthy controls. We found that sICAM-1 was elevated both in mild and malignant MSF. sE-selectin and sVCAM-1 were elevated only in patients with the malignant form and allowed to discriminate the two clinical subgroups. Their levels decreased after treatment with sE-selectin reaching control values at T2 whereas sVCAM-1 remained higher over the course of the malignant form. In patients with mild MSF, sP-selectin steadily increased after treatment, whereas it did not present any modification at any of the two sampling times in patients with the malignant form. Raised plasma levels of sE-selectin and sVCAM-1 reflect endothelial activation in malignant rickettsial disease and may be sufficiently early markers to influence the therapeutic decision.

• Authors: F Dignat-George, H Tissot-Dupont, G E Grau, L Camoin-Jau, D Raoult, J Sampol
• Journal: Thrombosis and haemostasis (Thromb Haemost) Vol. 82 Issue 6 Pg. 1610-3 (Dec 1999) ISSN: 0340-6245 [Print] Germany
• PMID: 10613643 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• E-Selectin
• Vascular Cell Adhesion Molecule-1

Topics

• Adult
• Biomarkers
• Boutonneuse Fever (blood, physiopathology)
• E-Selectin (blood)
• Female
• Humans
• Male
• Middle Aged
• Predictive Value of Tests
• Prognosis
• Vascular Cell Adhesion Molecule-1 (blood)