Abstract |
A serological survey of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections was carried out on a random sex- and age-stratified sample of 1006 individuals aged 25-64 years in the Seychelles islands. Anti-HBc and anti-HCV antibodies were detected using commercially available enzyme-linked immunosorbent assays (ELISA), followed by a Western blot assay in the case of a positive result for anti-HCV. The age-adjusted seroprevalence of anti-HBc antibodies was 8.0% (95% CI: 6.5-9.9%) and the percentage prevalence among males/females increased from 7.0/3.1 to 19.1/13.4 in the age groups 25-34 to 55-64 years, respectively. Two men and three women were positive for anti-HCV antibodies, with an age-adjusted seroprevalence of 0.34% (95% CI: 0.1-0.8%). Two out of these five subjects who were positive for anti-HCV also had anti-HBc antibodies. The seroprevalence of anti-HBc was significantly higher in unskilled workers, persons with low education, and heavy drinkers. The age-specific seroprevalence of anti-HBc in this population-based survey, which was conducted in 1994, was approximately three times lower than in a previous patient-based survey carried out in 1979. Although there are methodological differences between the two surveys, it is likely that the substantial decrease in anti-HBc prevalence during the last 15 years may be due to significant socioeconomic development and the systematic screening of blood donors since 1981. Because hepatitis C virus infections are serious and the cost of treatment is high, the fact that the prevalence of anti-HCV antibodies is at present low should not be an argument for not screening blood donors for anti-HCV and eliminating those who are positive.
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Authors | P Bovet, C Yersin, P Herminie, D Lavanchy, P C Frei |
Journal | Bulletin of the World Health Organization
(Bull World Health Organ)
Vol. 77
Issue 11
Pg. 923-8
( 1999)
ISSN: 0042-9686 [Print] Switzerland |
PMID | 10612888
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hepatitis B Antibodies
- Hepatitis C Antibodies
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Topics |
- Adult
- Age Distribution
- Alcoholism
(complications)
- Endemic Diseases
(statistics & numerical data)
- Female
- Hepatitis B
(blood, epidemiology, immunology)
- Hepatitis B Antibodies
(blood)
- Hepatitis C
(blood, epidemiology, immunology)
- Hepatitis C Antibodies
(blood)
- Humans
- Male
- Mass Screening
- Middle Aged
- Population Surveillance
- Risk Factors
- Seroepidemiologic Studies
- Sex Distribution
- Seychelles
(epidemiology)
- Socioeconomic Factors
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