The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom.

Abstract	The Mohr-Tranebjaerg syndrome (MTS), a neurodegenerative syndrome characterized by progressive sensorineural hearing loss, dystonia, mental retardation and blindness, is a mitochondrial disease caused by mutations in the deafness/dystonia peptide 1 (DDP1) gene. DDP1 shows similarity to the yeast proteins Tim9, Tim10 and Tim12, components of the mitochondrial import machinery for carrier proteins. Here, we show that DDP1 belongs to a large family of evolutionarily conserved proteins. We report the identification, chromosomal localization and expressional analysis of six human family members which represent further candidate genes for neurodegenerative diseases.
Authors	M F Bauer, U Rothbauer, N Mühlenbein, R J Smith, K Gerbitz, W Neupert, M Brunner, S Hofmann
Journal	FEBS letters (FEBS Lett) Vol. 464 Issue 1-2 Pg. 41-7 (Dec 24 1999) ISSN: 0014-5793 [Print] England
PMID	10611480 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Carrier Proteins DDP2 protein, E coli DNA, Complementary DNA-Binding Proteins Escherichia coli Proteins Fungal Proteins Membrane Proteins Membrane Transport Proteins Mitochondrial Membrane Transport Proteins Mitochondrial Precursor Protein Import Complex Proteins Mitochondrial Proteins Protein Precursors Saccharomyces cerevisiae Proteins TIM10 protein, S cerevisiae TIM13 protein, S cerevisiae TIM22 protein, S cerevisiae TIMM13 protein, human TIMM8A protein, human Tim9 protein, S cerevisiae
Topics	Amino Acid Sequence Blotting, Northern Carrier Proteins (chemistry, genetics, metabolism) Conserved Sequence DNA, Complementary (metabolism) DNA-Binding Proteins (chemistry, metabolism) Escherichia coli Proteins Evolution, Molecular Fungal Proteins (chemistry, metabolism) Humans Membrane Proteins (chemistry, genetics, metabolism) Membrane Transport Proteins Mitochondria (enzymology) Mitochondrial Membrane Transport Proteins Mitochondrial Precursor Protein Import Complex Proteins Mitochondrial Proteins Molecular Sequence Data Multigene Family Phylogeny Physical Chromosome Mapping Protein Precursors (chemistry, genetics, metabolism) Saccharomyces cerevisiae (enzymology) Saccharomyces cerevisiae Proteins Sequence Homology, Amino Acid Tissue Distribution

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