Two cases of pyoderma gangrenosum complicated with nasal septal perforation.

We report two patients with pyoderma gangrenosum complicated with nasal septal perforation. An 18-year-old woman and a 65-year-old man had typical lesions of pyoderma gangrenosum on the legs that responded well to oral prednisolone. Both patients complained of mild nasal discharge, and nasal fibroscopy revealed nasal septal perforation. Biopsy of the nasal lesions showed an active inflammatory infiltrate, mainly of neutrophils. Systemic investigations failed to show any pulmonary or renal lesions of Wegener's granulomatosis. Cytoplasmic immunofluorescent pattern antineutrophil cytoplasmic antibody was negative. In both cases, intense neutrophilic infiltration was observed not only in skin lesions but also in nasal lesions, which may indicate that the nasal lesions had a pathogenesis in common with the skin lesions.
AuthorsT Matsumura, K C Sato-Matsumura, M Ota, T Yokota, K Arita, K Kodama, D Inokuma, H Kobayashi
JournalThe British journal of dermatology (Br J Dermatol) Vol. 141 Issue 6 Pg. 1133-5 (Dec 1999) ISSN: 0007-0963 [Print] ENGLAND
PMID10606868 (Publication Type: Case Reports, Journal Article)
  • Adolescent
  • Aged
  • Female
  • Humans
  • Leg Ulcer (complications)
  • Male
  • Nasal Septum
  • Nose Diseases (complications)
  • Pyoderma Gangrenosum (complications)

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