Increased bile acid excretion and reduction of serum cholesterol after crenotherapy with salt-rich mineral water.
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| Abstract |
The effect of a spring mineral water from Montecatini (Italy) on bile acid excretion, and lipid and apolipoprotein serum levels was evaluated. The study was conducted in subjects with serum total cholesterol (TC) level > 240 mg/dL and LDL cholesterol (LDL-C) > 170 mg/dL, over a 9-week period, with 3 weeks of dietary stabilization, 3 weeks of active treatment, and 3 weeks of tap-water treatment as a control period. Serum lipids and apolipoproteins, total and fractionated bile acid excretion, gallbladder motility, and safety parameters were evaluated. Active treatment with mineral water significantly reduced serum TC by 7.5%, LDL-C by 12.5%, TC/HDL-cholesterol ratio by 6.3%, and apolipoprotein B by 6.3%; total fecal bile acid excretion was increased by 98.9%, and gallbladder volume was reduced by 40%. The reduction in serum and LDL-cholesterol levels observed during the active treatment period ran parallel to the increased excretion of bile acids in the stools. We suggest that salt-rich spring water treatment reduces serum and LDL-cholesterol levels in subjects with mild hypercholesterolemia through a mechanism of increased excretion of fecal bile acid sterols.
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| Authors | A Capurso, V Solfrizzi, F Panza, F Mastroianni, F Torres, A Del Parigi, A M Colacicco, C Capurso, G Nicoletti, B Veneziani, S Cellamare, A Scalabrino |
| Journal | Aging (Milan, Italy) (Aging (Milano)) Vol. 11 Issue 4 Pg. 273-6 (Aug 1999) ISSN: 0394-9532 [Print] Italy |
| PMID | 10605616 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't) |
| Chemical References |
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