Abstract | BACKGROUND: Accurate determination of lymph node involvement is a prerequisite for individualized therapy in patients with squamous cell carcinoma of the head and neck region. In a previous study, we showed that positron emission tomography (PET) with fluorodeoxyglucose F 18 with and without attenuation correction is superior to magnetic resonance imaging for this purpose in a scientific setting. OBJECTIVE: To evaluate the diagnostic accuracy of a shortened PET protocol (acquisition time, 20 minutes) in a routine clinical setting. DESIGN: The results of static, nonattenuation-corrected PET performed on patients in 2 bed positions starting 40 minutes after the intravenous injection of 370 MBq of fluorodeoxyglucose F 18 and the results of morphologic procedures (computed tomography and magnetic resonance imaging) were compared prospectively in 70 patients for lymph node staging. Postoperative pathologic findings served as a criterion standard. SETTING: An academic medical center. RESULTS: The diagnostic accuracy of PET for detecting "neck sides" with malignant involvement was superior to morphologic procedures, with a sensitivity and specificity of 87% and 94%, respectively, compared with computed tomographic values of 65% and 47% and magnetic resonance imaging values of 88% and 41%, respectively. CONCLUSION:
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Authors | R J Kau, C Alexiou, C Laubenbacher, M Werner, M Schwaiger, W Arnold |
Journal | Archives of otolaryngology--head & neck surgery
(Arch Otolaryngol Head Neck Surg)
Vol. 125
Issue 12
Pg. 1322-8
(Dec 1999)
ISSN: 0886-4470 [Print] United States |
PMID | 10604409
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Academic Medical Centers
- Adult
- Aged
- Carcinoma, Squamous Cell
(pathology, surgery)
- Combined Modality Therapy
- Female
- Fluorodeoxyglucose F18
- Head and Neck Neoplasms
(pathology, surgery)
- Humans
- Lymph Node Excision
- Lymph Nodes
(diagnostic imaging, pathology)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Neck
(diagnostic imaging, pathology)
- Sensitivity and Specificity
- Tomography, Emission-Computed
(methods)
- Tomography, X-Ray Computed
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