Iontophoresis for treatment of Peyronie's disease.

Abstract

PURPOSE:

We evaluate the efficacy of iontophoresis of dexamethasone, lidocaine and verapamil to treat Peyronie's disease.

MATERIALS AND METHODS:

In an uncontrolled prospective study 100 unselected patients with Peyronie's disease were treated with 3 weekly courses of iontophoresis. The drug mixture was administered by an electrical current of 5 mA. and a self-adhesive receptacle fixed to the penile skin overlying the plaque.

RESULTS:

Resolution of pain was observed in 96% of patients, plaque diminution in 53% and improvement of penile deviation in 37%. Impaired sexual function was improved in 19 of 43 patients (44%). The benefit of iontophoresis therapy was more pronounced in patients with a short history of disease. Because of lack of side effects and painless administration iontophoresis was well tolerated and accepted by all patients.

CONCLUSIONS:

Iontophoresis of dexamethasone, lidocaine and verapamil may be regarded as first line nonsurgical treatment for Peyronie's disease.

• Authors: C R Riedl, E Plas, P Engelhardt, K Daha, H Pflüger
• Journal: The Journal of urology (J Urol) Vol. 163 Issue 1 Pg. 95-9 (Jan 2000) ISSN: 0022-5347 [Print] United States
• PMID: 10604323 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Dexamethasone
• Lidocaine
• Verapamil

Topics

• Adult
• Aged
• Anti-Inflammatory Agents (administration & dosage)
• Dexamethasone (administration & dosage)
• Humans
• Iontophoresis
• Lidocaine (administration & dosage)
• Male
• Middle Aged
• Penile Induration (drug therapy)
• Prospective Studies
• Verapamil (administration & dosage)