Abstract |
The potential of B4121 to sensitize three intrinsically resistant human colon cancer cell lines (CaCo2, ATCC HTB 37; COLO 32 DM, ATCC CCL 220; HT-29, ATCC HTB 38) to vinblastine, doxorubicin, daunorubicin, paclitaxel, taxotere and cisplatin at a non-toxic, therapeutically relevant concentration of 0.25 microg/ml was compared with that of clofazimine at a similar concentration. The cell line expressing high levels of P-glycoprotein (P-gp), COLO 320 DM, was susceptible to chemosensitization by the experimental agents for the P-gp substrates ( paclitaxel, taxotere, daunorubicin, vinblastine and doxorubicin) but not for cisplatin. CaCo2 cells expressed lower levels of P-gp and were only marginally susceptible to sensitization by any one of these drugs, except in the case of sensitization by B4121 for doxorubicin and taxotere, whereas the HT-29, a P-gp negative cell line, was unaffected. The riminophenazines, especially B4121, might prove useful as combination treatment in circumventing P-gp mediated resistance of colon cancers.
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Authors | C E van Rensburg, G K Joone, J F O'Sullivan |
Journal | Oncology reports
(Oncol Rep)
2000 Jan-Feb
Vol. 7
Issue 1
Pg. 193-5
ISSN: 1021-335X [Print] Greece |
PMID | 10601617
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- B 4121
- Clofazimine
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Topics |
- ATP Binding Cassette Transporter, Subfamily B, Member 1
(analysis)
- Clofazimine
(analogs & derivatives, pharmacology)
- Colonic Neoplasms
(drug therapy)
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Flow Cytometry
- Humans
- Tumor Cells, Cultured
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