Abstract |
Neurohypophyseal hormones and several of their analogs, as well as N-terminal and C-terminal fragments, have been studied for their ability to attenuate puromycin-induced amnesia in mice. [ 8-Lysine]vasopressin, [8- arginine]vasopressin, and the analogs des-9- glycinamide-[ 8-lysine]vasopressin, [1-beta-mercaptopropionic acid, 8-lysine]vasopressin, [1,6-aminosuberic acid, 8-lysine]vasopressin, [4- leucine, 8-lysine]vasopressin, glycyl-glycyl-glycyl-[ 8-lysine]vasopressin, [1-beta-mercaptopropionic acid, 8-D- arginine]vasopressin, and [1,6-aminosuberic acid, 8- arginine]vasopressin are active. [8- Arginine]oxytocin as well as oxytocin and all of its other analogs tested are inactive with the striking exception of glycyl-glycyl-glycyl- oxytocin. The structural aspects of the neurohypophyseal hormones which appear to be important for significant activity in memory consolidation include the combination of a cyclic moiety containing the Tyr and Phe residues along with a basic residue in position 8. Another series of active compounds comprises C-terminal neurohypophyseal peptides and analogs thereof, including the naturally occurring Pro-Leu-Gly-NH2 and, most surprisingly, Leu-Gly-NH2, as well as its derivatives D-Leu-Gly-NH2 and the diketopiperazine, cyclo(-Leu-Gly-).
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Authors | R Walter, P L Hoffman, J B Flexner, L B Flexner |
Journal | Proceedings of the National Academy of Sciences of the United States of America
(Proc Natl Acad Sci U S A)
Vol. 72
Issue 10
Pg. 4180-4
(Oct 1975)
ISSN: 0027-8424 [Print] United States |
PMID | 1060098
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Pituitary Hormones, Posterior
- Vasopressins
- Puromycin
- Oxytocin
- Vasotocin
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Topics |
- Amnesia
(chemically induced, drug therapy)
- Animals
- Brain
(drug effects, physiology)
- Humans
- Memory
(drug effects)
- Mice
- Oxytocin
(pharmacology, therapeutic use)
- Pituitary Hormones, Posterior
(therapeutic use)
- Puromycin
- Structure-Activity Relationship
- Vasopressins
(pharmacology, therapeutic use)
- Vasotocin
(pharmacology, therapeutic use)
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