Abstract | BACKGROUND: METHOD: We analyzed the prevalence of long-term complications related to the native heart in the heterotopic heart transplant and attempted to gain insight into the potential risk to a native heart after receiving a left ventricular assist device. RESULTS: Between December 1984 and December 1994, 16 patients (13 men, 3 women, ranging in age from 37 to 60 years) underwent heterotopic heart transplant at the University of Pittsburgh. The 1- and 5-year survival rate after the transplant was 81% and 44%, respectively. Actuarial freedom from complications related to the native heart after 1 year and 4 years was ventricular arrhythmia: 85%, 75%; ischemic disease: 85%, 64%; valvular disease: 100%, 88%; and thromboembolism: 85%, 58%. Of these complications, thromboembolism was not considered in determining actuarial freedom from complications because thromboembolism should be regarded as a device-related complication rather than as a native-heart-related complication for left ventricular assist device recipients. Consequently, actuarial freedom from all complications excluding thromboembolism was 70% after 1 year and 50% after 4 years. In addition, the hazard function curve remains constant up to 80 months after the operation without significant differences among the yearly ratios. CONCLUSIONS: This analysis suggests that cautious observation of the native heart's long-term performance is necessary for the left ventricular assist device recipient.
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Authors | O Tagusari, R L Kormos, A Kawai, K Yamazaki, S M Pham, B G Hattler, S Murali, B P Griffith |
Journal | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
(J Heart Lung Transplant)
Vol. 18
Issue 11
Pg. 1111-9
(Nov 1999)
ISSN: 1053-2498 [Print] United States |
PMID | 10598735
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Adult
- Cardiac Catheterization
- Female
- Heart Transplantation
- Heart-Assist Devices
(adverse effects)
- Hemodynamics
- Humans
- Male
- Middle Aged
- Prevalence
- Prognosis
- Retrospective Studies
- Risk Factors
- Survival Rate
- Tachycardia, Ventricular
(epidemiology, etiology, physiopathology)
- Thromboembolism
(epidemiology, etiology, physiopathology)
- Transplantation, Heterotopic
- United States
(epidemiology)
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