Increased pressure in pulmonary artery is connected among other things with increased
endothelin plasma concentration. The aim of the study was to assess plasma
endothelin concentration in patients with
pulmonary hypertension. The analysis comprised 22 patients with increased pressure in pulmonary artery in the course of
pulmonary thromboembolism or chronic exacerbated left ventricular failure and 10 patients with chronic exacerbated left ventricular failure without
pulmonary hypertension. Plasma
endothelin concentration was measured in pulmonary artery and capillary wedge pressure were evaluated with Swan-Ganz
catheter and also peripheral and pulmonary vascular resistance were calculated.
Endothelin plasma concentration in peripheral vein was compared between patients and healthy volunteers. Plasma
endothelin concentration in pulmonary artery, peripheral artery and vein was higher in patients with
pulmonary hypertension than in patients with chronic exacerbated left ventricular failure without
pulmonary hypertension. Plasma
endothelin concentration in patients with chronic exacerbated left ventricular failure without
pulmonary hypertension was higher in pulmonary artery than in peripheral artery and vein. At these patients plasma
endothelin concentration in the peripheral vein didn't differ significantly from the healthy volunteers.