Abstract |
We report a case of Graves' hyperthyroidism in a 34-year-old pregnant woman treated with propylthiouracil (PTU) complicated by the development of a fetal goiter. Because of the fetal goiter and normal maternal thyroid function tests, the PTU was discontinued. Over the next 10 weeks, there was a progressive decrease in the fetal thyroid volume as documented by ultrasonography. The fetal neck returned to a normal flexed position, fetal growth and amniotic fluid remained normal, and the patient remained asymptomatic. A normal infant was delivered at term. This is the first report to demonstrate that noninvasive management may be appropriate for fetuses with goiter caused by antithyroid drug therapy.
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Authors | M R Ochoa-Maya, M C Frates, A Lee-Parritz, E W Seely |
Journal | Thyroid : official journal of the American Thyroid Association
(Thyroid)
Vol. 9
Issue 11
Pg. 1111-4
(Nov 1999)
ISSN: 1050-7256 [Print] United States |
PMID | 10595460
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antithyroid Agents
- Propylthiouracil
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Topics |
- Adult
- Antithyroid Agents
(adverse effects)
- Female
- Fetal Diseases
(chemically induced, therapy)
- Goiter
(chemically induced, therapy)
- Graves Disease
(drug therapy)
- Humans
- Pregnancy
- Pregnancy Complications
(drug therapy)
- Propylthiouracil
(adverse effects)
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