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Resolution of fetal goiter after discontinuation of propylthiouracil in a pregnant woman with Graves' hyperthyroidism.

Abstract
We report a case of Graves' hyperthyroidism in a 34-year-old pregnant woman treated with propylthiouracil (PTU) complicated by the development of a fetal goiter. Because of the fetal goiter and normal maternal thyroid function tests, the PTU was discontinued. Over the next 10 weeks, there was a progressive decrease in the fetal thyroid volume as documented by ultrasonography. The fetal neck returned to a normal flexed position, fetal growth and amniotic fluid remained normal, and the patient remained asymptomatic. A normal infant was delivered at term. This is the first report to demonstrate that noninvasive management may be appropriate for fetuses with goiter caused by antithyroid drug therapy.
AuthorsM R Ochoa-Maya, M C Frates, A Lee-Parritz, E W Seely
JournalThyroid : official journal of the American Thyroid Association (Thyroid) Vol. 9 Issue 11 Pg. 1111-4 (Nov 1999) ISSN: 1050-7256 [Print] United States
PMID10595460 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antithyroid Agents
  • Propylthiouracil
Topics
  • Adult
  • Antithyroid Agents (adverse effects)
  • Female
  • Fetal Diseases (chemically induced, therapy)
  • Goiter (chemically induced, therapy)
  • Graves Disease (drug therapy)
  • Humans
  • Pregnancy
  • Pregnancy Complications (drug therapy)
  • Propylthiouracil (adverse effects)

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