Shini-san inhibits mast cell-dependent immediate-type allergic reactions.

Abstract

Shini-San has been used for treatment of allergic disease in Korea. However, its effect in experimental models remains unknown. The mast cell plays a pivotal role in initiating allergic response by secreting intracytoplasmic granular mediators such as histamine. The present report describes an inhibitory effect of Shini-San on mast cell-mediated immediate-type allergic reactions. Topical application of compound 48/80 can induce an ear swelling response in normal (WBB6F1(-)+/+) mice but not in congenic mast cell-deficient WBB6F1-W/WV mice. Shini-San inhibited concentration-dependent mast cell-dependent ear swelling response induced by compound 48/80 in normal mice. Shini-San inhibited concentration-dependent passive cutaneous anaphylaxis induced by anti-dinitrophenyl (DNP) immunoglobulin E (IgE) in rats by topical application. Shini-San also inhibited in concentration-dependent fashion the histamine release from the rat peritoneal mast cells by compound 48/80 or anti-DNP IgE. Moreover, Shini-San had a significant inhibitory effect on compound 48/80-induced systemic anaphylactic reaction. These results indicate that Shini-San inhibits immediate type allergic reactions by inhibition of mast cell degranulation in vivo and in vitro.

• Authors: H M Kim, Y H Lee, H J Chae, H R Kim, S H Baek, K S Lim, C Y Hwang
• Journal: The American journal of Chinese medicine (Am J Chin Med) Vol. 27 Issue 3-4 Pg. 377-86 ( 1999) ISSN: 0192-415X [Print] Singapore
• PMID: 10592847 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Allergic Agents
• Pharmaceutical Preparations
• Plant Extracts
• shini-san
• p-Methoxy-N-methylphenethylamine

Topics

• Animals
• Anti-Allergic Agents (pharmacology)
• Edema (chemically induced, prevention & control)
• Histamine Release (drug effects)
• Hypersensitivity, Immediate (drug therapy, immunology, metabolism)
• Male
• Mast Cells (drug effects, metabolism)
• Mice
• Mice, Inbred C57BL
• Passive Cutaneous Anaphylaxis (drug effects)
• Pharmaceutical Preparations
• Plant Extracts (pharmacology)
• Rats
• Rats, Wistar
• p-Methoxy-N-methylphenethylamine (antagonists & inhibitors, pharmacology)