Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats.

Abstract

Punicalagin and punicalin were isolated from the leaves of Terminalia catappa L. In this study, we evaluated the anti-inflammatory activity of punicalagin and punicalin carrageenan-induced hind paw edema in rats. After evaluation of the anti-inflammatory effects, the edema rates were increased by carrageenan administration and reduced by drug treatment. After 4 hr of carrageenan administration, the best effect group was the punicalagin (10 mg/kg) treated group (inhibition rate was 58.15%), and the second was the punicalagin (5 mg/kg)-treated group (inhibition rate was 39.15%). However, even if the anti-inflammatory activity of punicalagin was the same as punicalin at the 5 mg/kg dose, the inhibition effect from larger doses of punicalagin was increased, but there was a decrease with a larger dose of punicalin. The data showed that both punicalagin and punicalin exert anti-inflammatory activity, but treatment with larger doses of punicalin may induce some cell damages.

• Authors: C C Lin, Y F Hsu, T C Lin
• Journal: The American journal of Chinese medicine (Am J Chin Med) Vol. 27 Issue 3-4 Pg. 371-6 ( 1999) ISSN: 0192-415X [Print] Singapore
• PMID: 10592846 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antioxidants
• Hydrolyzable Tannins
• Tannins
• punicalagin
• punicalin
• Carrageenan
• Indomethacin

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Antioxidants (pharmacology)
• Carrageenan
• Hydrolyzable Tannins
• Indomethacin (pharmacology)
• Inflammation (chemically induced, drug therapy)
• Kinetics
• Male
• Rats
• Rats, Inbred WKY
• Tannins (pharmacology)