Abstract |
There is growing evidence for the involvement of oxidative stress and mitochondrial respiratory failure in nigral neuronal death in Parkinson's disease (PD). We report increased immunoreactivity of 8-oxo-dGTPase (8-oxo-7, 8-dihydrodeoxyguanosine triphosphatase [hMTH1]), an enzyme known to play an important role in controlling spontaneous mutagenesis, and 8-oxo-7, 8-deoxyguanosine (8-oxo-dG) in the mitochondria of the substantia nigra of 6 PD patients. Our results suggest that hMTH1 might be a useful marker of oxidative stress and can be used to explore the relation between such oxidative stress and genomic instability.
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Authors | H Shimura-Miura, N Hattori, D Kang, K Miyako, Y Nakabeppu, Y Mizuno |
Journal | Annals of neurology
(Ann Neurol)
Vol. 46
Issue 6
Pg. 920-4
(Dec 1999)
ISSN: 0364-5134 [Print] United States |
PMID | 10589547
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- 8-Hydroxy-2'-Deoxyguanosine
- Phosphoric Monoester Hydrolases
- 8-oxodGTPase
- DNA Repair Enzymes
- Deoxyguanosine
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Topics |
- 8-Hydroxy-2'-Deoxyguanosine
- Biomarkers
- DNA Repair Enzymes
- Deoxyguanosine
(analogs & derivatives, analysis)
- Humans
- Immunohistochemistry
- Mitochondria
(enzymology, pathology)
- Models, Chemical
- Multiple System Atrophy
(enzymology)
- Neurons
(enzymology, pathology)
- Oxidative Stress
- Parkinson Disease
(enzymology, pathology)
- Phosphoric Monoester Hydrolases
(metabolism)
- Reference Values
- Substantia Nigra
(enzymology, pathology)
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