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Radiotherapy to control CNS lymphomatoid granulomatosis: a case report and review of the literature.

Abstract
Lymphomatoid granulomatosis (LG) is an uncommon but potentially fatal disease. The disease primarily involves the lungs; however, skin, renal, and central nervous system (CNS) are seen in varying proportions. Neurological involvement occurs in one third of the patients, and confers a worse prognosis. The use of radiotherapy to treat CNS involvement in LG has not been well studied. We report a case of a 33-year-old man with multiple CNS lesions treated successfully with radiotherapy and review 6 other cases in the literature using similar treatment. These cases support the use of radiotherapy for CNS involvement in LG.
AuthorsT M Petrella, I R Walker, G W Jones, B Leber
JournalAmerican journal of hematology (Am J Hematol) Vol. 62 Issue 4 Pg. 239-41 (Dec 1999) ISSN: 0361-8609 [Print] United States
PMID10589080 (Publication Type: Case Reports, Journal Article, Review)
CopyrightCopyright 1999 Wiley-Liss, Inc.
Chemical References
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone
Topics
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Brain Neoplasms (diagnosis, radiotherapy)
  • Cyclophosphamide (administration & dosage)
  • Doxorubicin (administration & dosage)
  • Humans
  • Lung Neoplasms (diagnosis, therapy)
  • Lymphomatoid Granulomatosis (diagnosis, radiotherapy, therapy)
  • Magnetic Resonance Imaging
  • Male
  • Prednisone (administration & dosage)
  • Remission Induction
  • Vincristine (administration & dosage)

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