Abstract |
N-methylmorpholine, which is used as a catalyst in polyurethane foams producing, in solvents, stabilizing agents, and corrosion inhibitors, was administered to female rats by gavage at 100, 200, 600, and 900 mg/kg during organogenesis. It did not exhibit selective toxicity toward the developing conceptus. This compound administered to pregnant females was fetotoxic and teratogenic in the presence of maternal toxicity. N-methylmorpholine induced anophthalmia, internal hydrocephalus, and hydronephrosis but only at one dose which was also maternotoxic. Teratogenesis Carcinog. Mutagen. 19:369-376, 1999.
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Authors | K Sitarek |
Journal | Teratogenesis, carcinogenesis, and mutagenesis
(Teratog Carcinog Mutagen)
Vol. 19
Issue 6
Pg. 369-76
( 1999)
ISSN: 0270-3211 [Print] United States |
PMID | 10587407
(Publication Type: Journal Article)
|
Copyright | Copyright 1999 Wiley-Liss, Inc. |
Chemical References |
- Morpholines
- Teratogens
- 4-methylmorpholine
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Topics |
- Abnormalities, Drug-Induced
- Administration, Oral
- Animals
- Anophthalmos
(chemically induced)
- Dose-Response Relationship, Drug
- Female
- Fetal Resorption
(chemically induced)
- Fetus
(drug effects)
- Hydrocephalus
(chemically induced)
- Hydronephrosis
(chemically induced)
- Litter Size
(drug effects)
- Maternal-Fetal Exchange
- Morpholines
(administration & dosage, toxicity)
- Pregnancy
- Rats
- Teratogens
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