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Maternal and fetal toxicity of N-methylmorpholine by oral administration in rats.

Abstract
N-methylmorpholine, which is used as a catalyst in polyurethane foams producing, in solvents, stabilizing agents, and corrosion inhibitors, was administered to female rats by gavage at 100, 200, 600, and 900 mg/kg during organogenesis. It did not exhibit selective toxicity toward the developing conceptus. This compound administered to pregnant females was fetotoxic and teratogenic in the presence of maternal toxicity. N-methylmorpholine induced anophthalmia, internal hydrocephalus, and hydronephrosis but only at one dose which was also maternotoxic. Teratogenesis Carcinog. Mutagen. 19:369-376, 1999.
AuthorsK Sitarek
JournalTeratogenesis, carcinogenesis, and mutagenesis (Teratog Carcinog Mutagen) Vol. 19 Issue 6 Pg. 369-76 ( 1999) ISSN: 0270-3211 [Print] United States
PMID10587407 (Publication Type: Journal Article)
CopyrightCopyright 1999 Wiley-Liss, Inc.
Chemical References
  • Morpholines
  • Teratogens
  • 4-methylmorpholine
Topics
  • Abnormalities, Drug-Induced
  • Administration, Oral
  • Animals
  • Anophthalmos (chemically induced)
  • Dose-Response Relationship, Drug
  • Female
  • Fetal Resorption (chemically induced)
  • Fetus (drug effects)
  • Hydrocephalus (chemically induced)
  • Hydronephrosis (chemically induced)
  • Litter Size (drug effects)
  • Maternal-Fetal Exchange
  • Morpholines (administration & dosage, toxicity)
  • Pregnancy
  • Rats
  • Teratogens

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