Anti-pressor effect of a Chinese-Japanese herbal medicine, saiko-ka-ryukotsu-borei-to on hemodynamics in rabbits.

Abstract

Saiko-ka-ryukotsu-borei-to (TJ-12) is a traditional Chinese-Japanese medicinal mixture clinically used for the treatment of hypertension and/or atherosclerosis concurrent with neurotic disorders. Study on the effect of TJ-12 on the vasoconstriction of cutaneous arterioles induced by nor-adrenaline (NA) was carried out using a rabbit ear chamber (REC) under conscious conditions. Before and after oral administration of TJ-12 everyday for 2 weeks, the same position of an arteriole within a REC was analyzed using an image shearing monitor every minute up to 15 min after varying doses (0.3, 1.0, 3.0 and 10.0 micrograms/kg i.v.) of NA. The changes of mean arteriolar diameter and vasomotion amplitude, before and after feeding of TJ-12 (1% w/w) supplemented diet were compared in the same position. Consequently, the pretreatment with TJ-12 significantly attenuated the changes of mean diameter of NA-induced vasoconstriction and also shortened its duration. In addition, concurrent with its cutaneous microcirculatory response, the pretreatment with TJ-12 systemically suppressed the increase of blood pressure under NA-induced vasoconstriction. These results suggest that the anti-pressor effect of TJ-12 might be apparently attributable to the inhibition of NA-induced vasoconstriction.

• Authors: H Okano, C Ohkubo
• Journal: In vivo (Athens, Greece) (In Vivo) 1999 Jul-Aug Vol. 13 Issue 4 Pg. 333-7 ISSN: 0258-851X [Print] Greece
• PMID: 10586374 (Publication Type: Journal Article)

Chemical References

• Drugs, Chinese Herbal
• saiko-ka-ryukotsu-borei-to
• Norepinephrine

Topics

• Animals
• Arterioles (drug effects, physiology)
• Blood Pressure (drug effects)
• Diffusion Chambers, Culture
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Drugs, Chinese Herbal (pharmacology)
• Heart Rate (drug effects)
• Male
• Microcirculation (drug effects)
• Norepinephrine (pharmacology)
• Rabbits
• Skin (blood supply, drug effects)
• Time Factors
• Vasoconstriction (drug effects, physiology)