Abstract | BACKGROUND: METHODS: RESULTS: In Groups 1 and 2, a significant decrease in the number of inflammatory lesions was found at the end of 3 and 6 months of treatment, and even after discontinuation of therapy for 6 months. Before treatment, patients in Group 1 showed signs of biochemical hyperandrogenism, including elevated levels of serum testosterone (T), androstenedione (A), and dehydroepiandrosterone sulfate ( DHEA-S), as well as a decreased level of sex hormone-binding globulin (SHBG). A decrease in circulating T and A, and an elevation in serum SHBG were found 3 and 6 months after treatment in Group 1. In Group 2, clinical improvement of acne was achieved by flutamide alone without alteration in circulating androgens (including T, A, and DHEA-S). Similarly, no change in serum androgens was observed in the women of Group 3 after treatment. CONCLUSION:
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Authors | H S Wang, T H Wang, Y K Soong |
Journal | Changgeng yi xue za zhi
(Changgeng Yi Xue Za Zhi)
Vol. 22
Issue 3
Pg. 423-32
(Sep 1999)
China (Republic : 1949- ) |
PMID | 10584414
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Androgen Antagonists
- Estrogens
- Progestins
- Sex Hormone-Binding Globulin
- Testosterone
- Flutamide
- Luteinizing Hormone
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Topics |
- Acne Vulgaris
(blood, drug therapy)
- Adult
- Amenorrhea
(blood)
- Androgen Antagonists
(therapeutic use)
- Estrogens
(administration & dosage)
- Female
- Flutamide
(therapeutic use)
- Humans
- Luteinizing Hormone
(blood)
- Oligomenorrhea
(blood)
- Progestins
(administration & dosage)
- Sex Hormone-Binding Globulin
(analysis)
- Testosterone
(blood)
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