The effect of tumor size on F-18-labeled fluorodeoxyglucose and fluoroerythronitroimidazole uptake in a murine sarcoma model.

Abstract

The purpose of this study was to evaluate the effect of tumor size on the uptake of 18F-fluorodeoxyglucose (FDG) and fluoroerythronitroimidazole (FETNIM) in a murine sarcoma model. ICR mice were xenografted with sarcoma 180 cell line and tumors were allowed to grow to a weight of 0.26-5.82 grams. 18F-FDG and 18F-FETNIM were injected intravenously in separate groups of mice, and after 1 hr, the tumors were excised and radiotracer uptake was measured. In another group of mice tumors were autoradiographically analyzed and subjected to H & E staining. In both the FDG and FETNIM group, per-gram radiotracer uptake by a tumor was inversely proportional to tumor weight. 18F-FETNIM correlated more (r = -0.593, p < 0.05) than 18F-FDG (r = -0.447, p < 0.05). Autoradiographic studies revealed that FDG accumulated in viable tumor areas, whereas FETNIM accumulated in both viable and partially necrotic areas. In the case of 18F-FETNIM, a direct correlation between tumor weight and the no-uptake-area to total-tumor-area was demonstrated. We concluded that increased tumor size is associated with decreased uptake of 18F-FDG and FETNIM, though this depends on the type of radiotracers and distribution of necrosis.

• Authors: J K Chung, Y S Chang, Y J Lee, Y J Kim, J M Jeong, D S Lee, J J Jang, M C Lee
• Journal: Annals of nuclear medicine (Ann Nucl Med) Vol. 13 Issue 5 Pg. 303-8 (Oct 1999) ISSN: 0914-7187 [Print] Japan
• PMID: 10582799 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Fluorine Radioisotopes
• Nitroimidazoles
• fluoroerythronitroimidazole
• Fluorodeoxyglucose F18

Topics

• Animals
• Autoradiography
• Fluorine Radioisotopes
• Fluorodeoxyglucose F18
• Male
• Mice
• Mice, Inbred ICR
• Necrosis
• Nitroimidazoles
• Sarcoma 180 (diagnostic imaging, pathology)
• Tomography, Emission-Computed