Tissue reactivity to poliglecaprone 25 in the feline linea alba.

Abstract

OBJECTIVE:

To use poliglecaprone 25 for all ligations and closure in routine feline ovariohysterectomies and evaluate maintenance of tissue approximation and tissue reaction to the suture.

STUDY DESIGN:

Prospective, descriptive study.

ANIMALS:

Twenty four female cats.

METHODS:

Ovariohysterectomies were performed in all cats. Abdominal incisions were inspected on days 1, 3, 7, 14, and 28 for dehiscence and swelling. All cats were euthanatized postoperatively, group 1 on day 7; group 2 on day 14; and group 3 on day 28. The peritoneal cavity was inspected for adhesions and all abdominal incisions were collected en bloc. Each linea alba was histologically evaluated and the inflammatory reaction was characterized.

RESULTS:

Dehiscence did not occur in any of the 24 cats. The incisional swelling on day 1 was significantly smaller than on day 7, and the swelling on day 14 was significantly smaller than on days 1, 3, and 7 (P < .05). Intra-abdominal adhesions were found in all groups with the greatest number associated with the peritoneum at the incision site. Tissue reactions in group 1 were pyogranulomatous or fibromononuclear, group 2 were granulomatous or fibromononuclear, and group 3 were pyogranulomatous, granulomatous, fibromononuclear or fibrous. Eosinophilic infiltration was seen in 3 of the 8 cats in group 1.

CONCLUSIONS:

Incisional swelling and inflammatory reactions seen with poliglecaprone 25 were consistent with those anticipated after implantation of suture in a surgically created wound.

CLINICAL RELEVANCE:

Poliglecaprone 25 appears to be an acceptable suture for use in feline ovariohysterectomy. It causes a relatively short-lived inflammatory response.

• Authors: A Runk, S W Allen, E A Mahaffey
• Journal: Veterinary surgery : VS (Vet Surg) 1999 Nov-Dec Vol. 28 Issue 6 Pg. 466-71 ISSN: 0161-3499 [Print] United States
• PMID: 10582744 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Dioxanes
• Polyesters
• glycolide E-caprolactone copolymer

Topics

• Abdomen
• Animals
• Cats (surgery)
• Dioxanes (adverse effects)
• Female
• Hysterectomy (methods, veterinary)
• Inflammation (chemically induced, veterinary)
• Omentum
• Ovariectomy (veterinary)
• Peritoneal Diseases (veterinary)
• Polyesters (adverse effects)
• Postoperative Period
• Prospective Studies
• Skin (drug effects, pathology)
• Surgical Wound Dehiscence (veterinary)
• Suture Techniques (veterinary)
• Sutures (veterinary)
• Tissue Adhesions (veterinary)